Approach

Here, we study a connectome of a millimeter-cubed volume of mouse visual cortex (MICrONS Consortium et al. 2021). The dataset is stored in a CAVE database (Dorkenwald et al. 2023), which tracks the edits which are made over time to the segmentation.

We further focused on a subset of the data which received extensive proofreading, namely, a set of inhibitory neurons located in a column spanning the entire cortical depth (Schneider-Mizell et al. 2023).

References

Dorkenwald, Sven, Casey M. Schneider-Mizell, Derrick Brittain, Akhilesh Halageri, Chris Jordan, Nico Kemnitz, Manual A. Castro, et al. 2023. “CAVE: Connectome Annotation Versioning Engine.” http://biorxiv.org/lookup/doi/10.1101/2023.07.26.550598.

MICrONS Consortium, J. Alexander Bae, Mahaly Baptiste, Caitlyn A. Bishop, Agnes L. Bodor, Derrick Brittain, JoAnn Buchanan, et al. 2021. “Functional Connectomics Spanning Multiple Areas of Mouse Visual Cortex.” http://dx.doi.org/10.1101/2021.07.28.454025.

Schneider-Mizell, Casey M, Agnes Bodor, Derrick Brittain, JoAnn Buchanan, Daniel J. Bumbarger, Leila Elabbady, Daniel Kapner, et al. 2023. “Cell-Type-Specific Inhibitory Circuitry from a Connectomic Census of Mouse Visual Cortex.” http://dx.doi.org/10.1101/2023.01.23.525290.